OSI 906AA
Linsitinib
CAS: 867160-71-2
Molecular Formula: C26H23N5O
OSI 906AA - Names and Identifiers
OSI 906AA - Physico-chemical Properties
| Molecular Formula | C26H23N5O |
| Molar Mass | 421.49 |
| Density | 1.39 |
| Melting Point | >175°C (dec.) |
| Solubility | Soluble in DMSO (up to 30 mg/ml) |
| Appearance | solid |
| Color | Yellow |
| pKa | 14.84±0.40(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| In vitro study | OSI-906 inhibited IGF-IR activation of autophosphorylation and downstream signaling proteins AKT, ERK1/2 and S6 kinase with an IC50 of 0.028 to 0.13 μm. OSI-906 the target protein forms an intermediate structural morphology by interacting with the C- helix. OSI-906 effect on liver microsomes, with good metabolic stability. OSI-906 concentration of 1 m, complete inhibition of IR and IGF-IR phosphorylation. OSI-906 inhibits proliferation of several tumor cell lines, including non-small cell lung cancer and colorectal cancer (CRC) tumor cell lines, with EC50 of 0.021 to 0.810 μm. OSI-906 inhibited IGF-IR activation of autophosphorylation and downstream signaling proteins AKT, ERK1/2 and S6 kinases with an IC50 of 0.028 to 0.13 μm. OSI-906 the target protein forms an intermediate structural morphology by interacting with the C- helix. OSI-906 effect on liver microsomes, with good metabolic stability. OSI-906 concentration of 1 m, complete inhibition of IR and IGF-IR phosphorylation. OSI-906 inhibits proliferation of several tumor cell lines, including non-small cell lung cancer and colorectal cancer (CRC) tumor cell lines, with EC50 of 0.021 to 0.810 μm. |
| In vivo study | OSI-906 on IGF-IR-driven xenograft tumor mouse model, inhibit tumor growth, at a dose of 75 mg/kg treatment, resulting in 100% TGI and 55% decline, at a dose of 25 mg/kg treatment, results in 60% TGI, no regression. Treatment of dogs, rats and mice OSI-906 induced different elimination half-lives of 1.18 hours, 2.64 hours and 2.14 hours, respectively. OSI-906 female Sprague-Dawley rats and female CD-1 mice were treated individually at different doses, once a day, and the Vmax values were not proportional to the OSI-906 dose. OSI-906 according to the dose of 25 mg/kg treatment for 12 days, improve the blood sugar value. OSI-906 treatment of a IGF-IR-driven human full-length human IGF-IR (LISN) transplanted mouse model alone at a dose of 75 mg/kg maximally inhibited phosphorylation by IGF-IR (80%) between 4 and 24 hours, plasma drug concentrations ranged from 26.6 to 4.77 μm. OSI-906 at a dose of 60 mg/kg alone in NCI-H292 transplanted mice, 2,4,24 hours, inhibition of sugar absorption. OSI-906 in NCI-H292 transplantation mouse model, inhibit tumor growth. OSI-906 Inhibition of tumor growth in a IGF-IR-driven xenograft mouse model, treated at a dose of 75 mg/kg, resulting in 100% TGI and 55% regression, treated at a dose of 25 mg/kg, resulting in 60% TGI, there was no recession. Treatment of dogs, rats and mice OSI-906 induced different elimination half-lives of 1.18 hours, 2.64 hours and 2.14 hours, respectively. OSI-906 female Sprague-Dawley rats and female CD-1 mice were treated individually at different doses, once a day, and the V max value was not proportional to the OSI-906 dose. OSI-906 according to the dose of 25 mg/kg treatment for 12 days, improve the blood sugar value. OSI-906 treatment of a IGF-IR-driven human full-length human IGF-IR (LISN) transplanted mouse model alone at a dose of 75 mg/kg maximally inhibited phosphorylation by IGF-IR (80%) between 4 and 24 hours, plasma drug concentrations ranged from 26.6 to 4.77 μm. OSI-906 at a dose of 60 mg/kg alone in NCI-H292 transplanted mice, 2,4,24 hours, inhibition of sugar absorption. OSI-906 in NCI-H292 transplantation mouse model, inhibit tumor growth. |
OSI 906AA - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.372 ml | 11.862 ml | 23.724 ml |
| 5 mM | 0.474 ml | 2.372 ml | 4.745 ml |
| 10 mM | 0.237 ml | 1.186 ml | 2.372 ml |
| 5 mM | 0.047 ml | 0.237 ml | 0.474 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Featured ProductsSpot supply
Product Name: OSI-906 Visit Supplier Webpage Request for quotationCAS: 867160-71-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Linsitinib Request for quotationCAS: 867160-71-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: OSI-906 (Linsitinib) Visit Supplier Webpage Request for quotationCAS: 867160-71-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: OSI-906 Visit Supplier Webpage Request for quotationCAS: 867160-71-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Linsitinib Visit Supplier Webpage Request for quotationCAS: 867160-71-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: OSI-906 (Linsitinib) Visit Supplier Webpage Request for quotation
CAS: 867160-71-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 867160-71-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: OSI-906 Visit Supplier Webpage Request for quotationCAS: 867160-71-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Linsitinib Request for quotationCAS: 867160-71-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: OSI-906 (Linsitinib) Visit Supplier Webpage Request for quotationCAS: 867160-71-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: OSI-906 Visit Supplier Webpage Request for quotationCAS: 867160-71-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Linsitinib Visit Supplier Webpage Request for quotationCAS: 867160-71-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: OSI-906 (Linsitinib) Visit Supplier Webpage Request for quotation
CAS: 867160-71-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 867160-71-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History